Ryan Haasl

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Assistant Professor

Department of Biology

338 Gardner Hall

(608) 342-7330

haaslr@uwplatt.edu

 

Education

Ph.D., Genetics, University of Wisconsin -- Madison

M.A., Entomology, University of Kansas

B.S., Biology, University of Wisconsin -- Stevens Point

B.A., English and Philosophy, University of Wisconsin -- Milwaukee

 

TEACHING

Biology 1020     BioQuest

Biology 1650     The Unity of Life, Lab and lecture

Biology 3330     Genetics

 

FALL 2014 schedule

 

Undergraduate research

I believe it is important to provide students in the natural sciences with opportunity to perform meaningful research. This experience enriches their understanding of course content and prepares them for employment and postgraduate education. Currently I am engaged in several research areas. In most cases, I prefer that students have taken Biology 3330 (Genetics) before working with me because the work of our group requires a basic understanding of genetical concepts. However, I encourage all students interested in biological research in one of the RESEARCH TOPICS we're pursuing to contact me.

 

software and datasets

INVASION!

This software simulates the spread of Japanese hops in the riparian zones of the Driftless area. The user controls ecological and life history parameter values. Each year positional and genetic information of living plants are output. An R script is also provided to visualize results and perform population genetic analyses. The compressed files also provide a pdf with documentation.

To download source code, go to the GitHub repository and select "Download ZIP". Basic instructions are in the README file, while more detailed instructions are found in the invasion.pdf documentation file.

STRlink 

This software simulates 1Mb chromosomal segments with a selected SNP or microsatellite at it center (500kb). New mutation, recombination, and reproduction are all accounted for. We wrote this software to produce the simulated datasets detailed in Haasl, Johnson, and Payseur (2014). It requires the use of Hudson's ms program, which is bundled with our source code. Final source code available by 9/01/14

Datasets for Haasl, Johnson, and Payseur (2014)

Full autosomal scan of 85 individuals of Northwestern European ancestry (population CEU) using the ksk2(20) and ksk2(1) statistics detailed in Haasl, Johnson, and Payseur (2014). 

The following links will load the custom tracks into the UCSC human genome browser and open to all of chromosome 19 (takes a bit to load). However, any part of an autosome can be viewed by entering the desired region in the search box of the genome browser.

KSK2(20)

KSK2(1)

 

publications

         denotes UWP undergraduate student

01. Haasl RJ, Johnson RC, and Payseur BA (2014) The effects of microsatellite selection on linked sequence diversity. Genome Biology and Evolution, 6: 1843-1861.  PDF

02. Haasl RJ and Payseur BA (2014) Remarkable selective constraints on exonic dinucleotide repeats. Evolution, 68: 2737-2744. ABSTRACT

03. Gray MM, Wegmann D, Haasl RJ, White MA, Gabreil S, Searle JB,  Cuthbert RJ, Ryan PG, Payseur BA (2014) Demographic history of a recent invasion of house mice on the isolated island of Gough. Molecular Ecology, 23: 1923-1939.    ABSTRACT

04. Haasl RJ and Paysuer BA (2013) Microsatellites as targets of natural selection. Molecular Biology and Evolution, 30: 285-298.PDF

05. Haasl RJ, McCarty CA, and Payseur BA (2013) Genetic ancestry inference using support vector machines, and the active emergence of a unique American population. European Journal of Human Genetics, 21: 554-562.  PDF

06. Payseur BA, Jing P, Haasl RJ (2011) A genomic portrait of human microsatellite variation. Molecular Biology and Evolution, 28: 303-312.  get pdfPDF

07. Haasl RJ and Payseur BA (2011) Multi-locus inference of population structure: a comparison between single nucleotide polymorphisms and microsatellites. Heredity, 106: 158-171.    get PDFPDF

08. Haasl RJ and Payseur BA (2010) The number of alleles at a microsatellite defines the allele frequency spectrum and facilitates fast accurate estimation of θMolecular Biology and Evolution, 27: 2702-2715.  PDF

09. Simon DP, Meethal SV, Wilson AC, Gallego MJ, Weinecke SL, Bruce E, Lyons PF, Haasl RJ, Bowen RL, Atwood CS (2009) Activin receptor signaling regulates prostatic epithelial cell adhesion and viability. Neoplasia, 11: 365.

10. Chan HW, Liu T, Verdile G, Bishop G, Haasl RJ, Smith MA, Perry G, Martins RN, Atwood CS (2008) Copper induces apoptosis of neuroblastoma cells via post-translational regulation of the expression of Bcl-2-family proteins and the TxJ mouse is a better model of hepatic than brain Cu toxicity. Intl J. Clinical and Experimental Medicine, 1: 76.

11. Chen X, Han B, Fang J, Haasl RJ (2008) Large-scale Protein-Protein Interaction prediction using novel kernel methods. Intl J. of Data Mining and Bioinformatics, 2: 145-156.

12. Haasl RJ, Ahmadi MR, Meethal SV, Gleason CE, Johnson SC, Asthana S, Bowen RL, Atwood CS (2008) A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ε4 allele. BMC Medical Genetics, 9: 37.

13. Wilson AC, Salamat MS, Haasl RJ, Roche KM, Karande A, Meethal SV, Terasawa E, Bowen RL, Atwood CS (2006) Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression. Journal of Endocrinology, 191: 651-663.

14. Haasl RJ, Fang J (2006) Mining protein-protein interaction data. Current Bioinformatics, 1: 197-205.

15. Meethal SV, Gallego MJ, Haasl RJ, Petras SJ, Sgro JY, Atwood CS (2006) Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans. BMC Evolutionary Biology, 6: 103.

16. Fang J, Haasl RJ, Dong Y, Lushington GH (2005) Discover protein signatures from protein-protein interaction data. BMC Bioinformatics, 6: 277.

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